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Lisa A. Elferink, Ph.D. 301 University Blvd. Galveston, TX 77555-1069
Affiliations Associate Professor, Department of Physiology and Biophysics Member, Marine Biomedical Institute |
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Education
B.Sc. (Biochemistry, Physiology, Pharmacology), University of Adelaide, Australia, 1981
Ph.D. (Biochemistry) University of Adelaide, Australia, 1988
Postdoctoral, Stanford University, CA
Graduate Program Affiliations
Associate Member, Cell Biology Graduate Program
Associate Member, Human Biological Chemistry & Genetics Graduate Program
Associate Member, Neurosciences Graduate Program
Employment Opportunities in laboratory
Research Interests
Trafficking and Receptor Signaling
Our
research program focuses on understanding the molecular and cellular mechanisms
linking membrane trafficking with receptor- signaling. Membrane
trafficking is important for normal neural and cell function, including
neurotransmitter release, neurite extension, cell migration and invasion during
normal development or migration, and pathogen entry by phagocytosis. Recent
studies have shown a requirement for early endocytic trafficking in ligand-activated
receptor signaling.
Using a combination of molecular (e.g. mutagenesis), genetic (yeast-two
hybrid), biochemical (protein-protein interactions) and cellular (recombinant
viruses, confocal microscopy and digital imaging) approaches, we are examining
functionally important protein-protein interactions for trafficking through
early endosomes and how they regulate the signaling properties of
receptor-tyrosine kinases. Understanding these processes is critical for
defining how the endocytic trafficking of receptor tyrosine kinases regulates
normal cell function.
Our goal is to identify novel targets for drug development aimed at
treating human diseases involving aberrant receptor signaling in
vivo.
Cohen, R., Elferink, L.A., and Atlas, D. (2003) The C2A domain of synaptogamin alters the kinetics of voltage-gated Ca2+ channels Cav1.2 and Cav2.3. J. Biol. Chem. 278:9258-66.
Strick, D.J., Francescutti, D.M., Zhao, Y., and Elferink, L.A. (2002). Mammalian suppressor of Sec4 modulates the inhibitory effect of rab15 during early endocytosis. J. Biol. Chem, 277, 32722-32729.
Xu, W., Shy, M., Kamholtz, J., Elferink, L.A., Lilien, J., and Balsamo, J. (2001). Mutations in the cytoplasmic domain of PO reveal a role for PKC-mediated phosphorylation in adhesion and myelination. J. Cell Biol. 155, 439-446.
Zuk, P., and Elferink,
L. A. (2000) Rab15 differentially regulates early endocytic trafficking.
J. Biol. Chem. 275, 26754-26764.
Zuk, P., and Elferink,
L. A. (1999)Rab15 mediates an early endocytic event in Chinese Hamster Ovary
cells. J. Biol. Chem.274, 22303-22312.
Thomas, D.M.,
Ferguson, G.D., Herschman, H. R., and Elferink, L.A. (1999)
Functional
and biochemical analysis of the C2 domain of Synaptotagmin IV. Mol. Biol.
Cell.10, 2285-2295.
Ferguson, G. D.,
Thomas, D. M.,Elferink, L.A., and Herschman, H. R. (1999) Synthesis,
degradation and subcellular localization of synaptotagmin IV, a
neuronalimmediate early gene product. J. Neurochem. 72, 1821-1831.
Thomas, D.M., and Elferink,
L.A. (1998) Functional
Analysis of the C2A Domain of Synaptotagmin 1:Implications for Calcium Regulated
Secretion. J. Neurosci.18, 3511-3520.
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