Manning J

Manning J. Correia, Ph.D.

Jehu M. Robison Distinguished Professor

Ø B.A., Experimental Psychology, Emory University, Atlanta, GA, 1959

Ø M.A., Ph.D., Experimental Psychology, University of Alabama, Tuscaloosa, AL, 1963

Ø Postdoctoral, Naval Aerospace Medical Institute, Pensacola, FL 1963 - 1967

Ø Department of Physiology & Biophysics

Ø Department of Anatomy & Neurosciences

Ø Member, Cellular Physiology & Molecular Biophysics Graduate Program

Ø Member, Neuroscience Graduate Program

Ø Member, Cell Biology Graduate Program

Ø Adjunct Member, Marine Biomedical Institute

Contact Information:

Phone: 409-772-2708

Fax: 409-772-2694

Email: mjcorrei@utmb.edu

Research Interests:

My laboratory, funded by NIDCD-NIH, is concerned with the sensory organs of balance and hearing. We study the sensory cells (hair cells) and the primary afferents and efferents that innervate them. We use the techniques of electrophysiology (action potential and single channel analysis), immunohistochemistry (in situ RT-PCR and antibody labeling) and molecular biology (cloning, transfection, mutants and quantitative RT-PCR) to study potassium, sodium and calcium ion channels in hair cells. Also, we use these same techniques to study the nicotinic and muscarinic acetylcholine receptors in the membranes of the hair cells. Historically, my laboratory has used the above techniques to understand function, dysfunction and regeneration of hair cells and vestibular nerve fibers following exposure to unusual environments, including weightlessness in space, aging and pathological insults to the inner ear. Presently, we are concerned with hair cell channelopathy and we are conducting structure (amino-acid sequence) – function (single channel ionic currents) studies of the potassium ion channels in hair cells.

Research Figures:

Figure 1 – On-cell - Giga-ohm Figure 2 – Two state single channel recording from

seal of a CHO cell co-transfected a single ion channel molecule in a CHO cell expressing

with inward rectifier potassium the proteins described in Figure 1.

ion channel DNA and enhanced

green fluorescent Protein (EGFP).

Selected Publications:

Ricci, A.J. and Correia, M.J. Electrical response properties of avian lagena type II hair cells: A model system for vestibular filtering. Am. J. Physiol. 276 (Regulatory, Integrative and Comp. Physiol. 45): R943-R953, 1999.

Weng, T. and Correia, M.J. Regional distribution of Ionic currents and membrane voltage responses of type II vestibular hair cells in a slice of the pigeon’s semicircular canal crista and the utricular macula. J. Neurophysiol. 82: 2451-2461, 1999

Rennie, K.J. and Correia, M.J. Effects of cationic substitutions on delayed rectifier current in type I vestibular hair cells. J. Memb. Biol., 173, 139-149, 2000.

Kevetter, G.A., Blumberg, K.R., and Correia, M.J. Hair cell and supporting cell density and distribution in the normal and regenerating posterior crista ampullaris of the pigeon. Int. J. Dev. Neuroscience, 18: 855-867, 2000.

Rennie, K.J., Weng, T.X., Correia, M.J. Effects of KCNQ channel blockers on K⁺ currents in vestibular hair cells. Am J Physiol Cell Physiol 280: C473-C480, 2001.

Correia, M.J., Rennie, K.J., Koo, P. Return of potassium ion channels in regenerated hair cells: Possible pathways and the role of intracellular calcium signaling. Annals N.Y. Academy of Science, 942: 2001.

Masetto, S., Bosica, M., Correia, M.J., Ottersen, O.P, Zucca, G., Perin, P.,Vaul, P. Na⁺ currents in vestibular type I and type II hair cells of the embryo and adult chicken. J. Neurophysiol. 2003 Apr 17 [epub ahead of print]

and Internet guidelines.

Last updated: 06/08/05

Masetto, S., Bosica, M., Correia, M.J., Ottersen, O.P, Zucca, G., Perin, P.,Vaul, P. Na+ currents in vestibular type I and type II hair cells of the embryo and adult chicken. J. Neurophysiol. 2003 Apr 17 [epub ahead of print]

Masetto, S., Bosica, M., Correia, M.J., Ottersen, O.P, Zucca, G., Perin, P.,Vaul, P. Na⁺ currents in vestibular type I and type II hair cells of the embryo and adult chicken. J. Neurophysiol. 2003 Apr 17 [epub ahead of print]